If you have ever kicked off the covers at 3 a.m., forgotten a word mid-sentence, or felt your mood shift for no clear reason, you are not imagining it. And you are not alone. Menopause changes how your body feels, sleeps, digests and thinks. Those changes are real, they are common, and you deserve support that takes all of them seriously.
The good news is that you have more options than "just put up with it." Science increasingly shows that cellular health, digestion and well-studied plant botanicals all play a part in how comfortably you move through this transition. This guide explains what is happening in your body, which natural menopause relief options have research behind them, and how Immunotec She+ fits into a simple daily routine.
Key takeaways
- Frequent hot flashes and night sweats last a median of 7.4 years, according to the SWAN study.
- Falling estrogen affects temperature control, sleep, mood, digestion and your body's antioxidant defenses.
- Black cohosh and red clover are two of the most-studied botanicals for menopause support.
- She+ combines black cohosh, red clover, ginger and konjac glucomannan in one hormone-free daily jelly stick.
What happens to your body during menopause?
Menopause is officially reached 12 months after your last period. In the United States, the average age is 51. The years before it, called perimenopause, can start in your early to mid 40s. That is often when the first changes appear.
Most of what you feel comes back to one thing: hormonal balance during menopause shifts. Your ovaries gradually make less estrogen and progesterone. Estrogen does far more than regulate your cycle. It influences the brain's temperature center, sleep, mood chemistry, skin, bones, metabolism and even your gut.
Common menopause symptoms
- Hot flashes and night sweats. Sudden waves of heat, flushing and sweating, often at night.
- Sleep problems. Trouble falling asleep, waking at 3 a.m., or waking drenched.
- Mood swings and irritability. Feeling more anxious, tearful or short-tempered than usual.
- Menopause fatigue. A heavy tiredness that coffee does not fix.
- Menopause brain fog. Forgetfulness and trouble concentrating.
- Menopause bloating and digestive changes. Gas, bloating or irregularity that seems new.
These symptoms are not minor. In the Study of Women's Health Across the Nation (SWAN), published in JAMA Internal Medicine in 2015, women with frequent hot flashes and night sweats experienced them for a median of 7.4 years. That is a long time to feel uncomfortable.
Oxidative stress and aging
Estrogen has a lesser-known job. It helps protect cells from oxidative stress, the wear and tear caused when free radicals outnumber your antioxidant defenses. As estrogen declines, research shows markers of oxidative stress tend to rise. This is one reason menopause often coincides with changes in energy, skin and how quickly you recover. Supporting your body's own antioxidant systems, including glutathione, is part of aging well. You can read more in our article on glutathione and energy.
Natural menopause relief: what women are searching for
When women look for help, the same questions come up again and again:
- What are the best supplements for menopause?
- How can I stop night sweats naturally?
- Is there non-hormonal menopause relief that works?
- Does black cohosh work for hot flashes?
- How do I deal with menopause bloating and weight changes?
Many women want hormone-free menopause support. Some prefer a natural approach. Others cannot use hormone therapy for medical reasons. Lifestyle habits matter for everyone: a cool bedroom, regular movement, limiting alcohol and spicy food in the evening, and stress-relief practices. Botanical menopause supplements are the next step many women explore. Among them, two plants have the most research: black cohosh and red clover.
Introducing Immunotec She+: a modern approach to menopause support
She+ is a multi-symptom menopause support formula created by Immunotec specifically for women's wellness. Most menopause products focus on one thing, usually hot flashes. She+ was built around a different reality. Menopause rarely shows up as just one symptom.
One jelly stick, once a day
Tired of swallowing another handful of tablets? She+ comes as a delicious apple and blueberry jelly stick. You take one stick a day, straight from the pack. No water, no capsules, no chalky pills.
- 25 calories per 20 g stick
- No added sugar and no artificial colors
- Free from gluten, dairy and soy
- 20 sticks per box, or about 60 days with the She+ Set of 3
Immunotec She+ ingredients
Each stick combines four targeted ingredients that support hormonal and digestive health together:
- Black cohosh root extract (40 mg). The botanical most closely associated with menopause support. A 2023 review of 22 studies, summarized by the U.S. National Center for Complementary and Integrative Health (NCCIH), found black cohosh products potentially beneficial for menopause symptoms, with hot flashes showing improvement.*
- Red clover extract (40 mg). A natural source of isoflavones, plant compounds sometimes called phytoestrogens. A 2021 meta-analysis of placebo-controlled trials in Nutrients found red clover isoflavone extracts reduced hot flushes by about 1.7 per day more than placebo.*
- Ginger rhizome extract (100 mg). Used for centuries to support everyday digestive comfort, especially when bloating and sluggish digestion become part of midlife.*
- Glucomannan from konjac root (60 mg). A soluble plant fiber from the konjac root.*
Key benefits of She+ for menopausal women
Support for hot flashes and night sweats
Hot flashes are the most searched menopause symptom for a reason. They disrupt work, conversations and sleep. She+ pairs black cohosh and red clover, the two botanicals with the most research for vasomotor comfort, to help support relief from occasional hot flashes and night sweats.*
Mood and sleep support
Night sweats and poor sleep feed each other, and poor sleep feeds midlife fatigue and low mood. By supporting temperature comfort at night, She+ is designed to promote more restful sleep and everyday emotional balance.* For extra sleep support, many women pair it with a calming evening routine, and some look at Seren-T.
Digestive health during hormonal shifts
Here is something many women do not expect. Estrogen influences gut motility and the gut microbiome, so digestion can change during menopause. Bloating, gas and irregularity become common complaints. She+ includes ginger extract to support everyday digestive comfort, plus konjac glucomannan, a soluble plant fiber.*
Radiant aging from the inside out
Feeling good in midlife is about more than getting through the hard days. It is about long-term vitality. Red clover isoflavones have antioxidant properties, and a consistent daily routine helps you focus on how you want to feel for decades to come.* Many women build on She+ with Immunocal Platinum, which supports the body's own glutathione production for cellular health, and Calcium-D From Milk for bone support after menopause.*
Is She+ hormone replacement therapy?
No. She+ is a plant-based supplement with zero hormones, so it is not a form of HRT. Hormone therapy is a prescription treatment, and for some women it is the right choice. Talk with your healthcare provider before starting She+, especially if you use HRT or other medications, or have a history of liver problems or a hormone-sensitive condition such as breast cancer. NCCIH notes that rare liver problems have been reported in people taking black cohosh products, so contact your provider if you notice symptoms like dark urine or unusual fatigue. She+ is sweetened with xylitol, so store it away from dogs, for whom xylitol is toxic.
Your next step
Menopause is inevitable. Navigating it uncomfortably is not. With a few smart habits and the right support, this stage can feel steadier, clearer and more like you.
Ready to make it simple? Try Immunotec She+ as part of your daily routine. One apple and blueberry jelly stick, once a day. Give it a few weeks of consistent use, track how you feel, and share the results with your healthcare provider. Questions? Contact Andre and Tami. We are happy to help.
Keep reading
- What Is Perimenopause? How It Differs from Menopause
- What Does Black Cohosh Do? What the Evidence Says
- Non-Hormonal Approaches to Hot Flashes: What the Research Supports
- Sleep Changes During Perimenopause: Why They Happen and What Helps
- What to Ask Your Doctor About Menopause Supplements
Browse every guide in our Menopause Support Hub.
Frequently asked questions
What is the best natural supplement for menopause?
Black cohosh and red clover are among the most studied botanicals for menopause support, especially for hot flashes. Immunotec She+ combines both with ginger extract and konjac glucomannan in one daily jelly stick.
What are the ingredients in Immunotec She+?
Each 20 g stick contains black cohosh root extract (40 mg), red clover extract (40 mg), ginger rhizome extract (100 mg) and glucomannan from konjac root (60 mg), in an apple and blueberry jelly with no added sugar.
Is She+ safe to take with HRT?
She+ is a dietary supplement, not hormone replacement therapy. If you use HRT or any medication, talk with your healthcare provider before adding She+ to your routine.
Can I take She+ during perimenopause?
Yes. She+ is designed for the whole menopause transition, including perimenopause, when cycles, sleep, temperature and mood can start to change.
How long does it take for menopause supplements to work?
Most clinical studies of black cohosh and red clover run for about 8 to 12 weeks. Take She+ consistently, once a day, and track how you feel over several weeks.
References
- Avis NE, et al. Duration of menopausal vasomotor symptoms over the menopause transition (SWAN). JAMA Intern Med. 2015;175(4):531-539.
- National Center for Complementary and Integrative Health. Black Cohosh.
- Kanadys W, et al. Evaluation of clinical meaningfulness of red clover extract to relieve hot flushes and menopausal symptoms: a systematic review and meta-analysis. Nutrients. 2021;13(4):1258.
- Immunotec. She+ product information.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This article is for general education and is not medical advice. Talk with your healthcare provider before starting a supplement, especially if you are pregnant, nursing, take medication or have a medical condition.